Top of page
Health

Obesity worsens disability in multiple sclerosis

Closeup of obese elderly woman

Obesity is an aggravating factor in relapsing-remitting multiple sclerosis, the most common form of the disease. A recent study by the Unit of Neurology and Neurorehabilitation of the I.R.C.C.S. Neuromed in Pozzilli (Italy) confirms that lipid metabolism can have a role in determining the severity of multiple sclerosis.

Published in the Multiple Sclerosis Journal, the research, involving 140 patients, showed that at the time of diagnosis obese patients have a greater risk of presenting higher EDSS (Expanded Disability Status Scale) score, the tool commonly used to assess the severity of multiple sclerosis. Neuromed researchers have also investigated, from a biochemical point of view, the relationship between multiple sclerosis and excessive body weight, analyzing the levels of inflammation in the central nervous system and the lipids concentrations in the blood (cholesterol and triglycerides).

Multiple sclerosis is an inflammatory process, and the authors of the study have focused their investigation on some molecules involved in inflammation. Analysis of cerebrospinal fluid (collected with lumbar puncture) showed in obese patients higher levels of interleukin-6 (IL-6) and leptin, two molecules well known as promoters of the inflammatory process. In contrast, interleukin-13 (IL-13), with anti-inflammatory action, was reduced. Regarding lipid profile, higher levels of triglycerides and a higher ratio of total to HDL cholesterol have been correlated to higher IL-6 levels.

You might also like

Nurse talking with patient in wheelchair Nurse talking with patient in wheelchair

Enrollment and eligibility for Medicare for people with disabilities

Medicare is a government program designed to provide medical coverage…

microscopic photo of coronavirus microscopic photo of coronavirus

More caution in health services as cases rise

NSW Health has upgraded its COVID-19 risk rating to amber…

Close-up of child ear - black and white Close-up of child ear - black and white

Unlocking human inner ear for new therapies to improve hearing loss

An international research coalition has verified safe surgical access to…

young boy passes robotic therapy in rehabilitation center young boy passes robotic therapy in rehabilitation center

Study reveals changing treatment can help patients with Multiple Sclerosis

Monash University researchers have used the world’s largest Multiple Sclerosis…