Top of page
Health

New study may explain why people with autism are often highly sensitive to light and noise

a teenage with autism relaxing with rocking chair
Photo: jjwarren97

People with autism are highly sensitive to light, noise, and other sensory input. A new study in mice reveals a neural circuit that appears to underlie this hypersensitivity, offering a possible strategy for developing new treatments.

MIT and Brown University neuroscientists found that mice lacking a protein called Shank3, which has been previously linked with autism, were more sensitive to a touch on their whiskers than genetically normal mice. These Shank3-deficient mice also had overactive excitatory neurons in a region of the brain called the somatosensory cortex, which the researchers believe accounts for their over-reactivity.

There are currently no treatments for sensory hypersensitivity, but the researchers believe that uncovering the cellular basis of this sensitivity may help scientists to develop potential treatments.

“We hope our studies can point us to the right direction for the next generation of treatment development,” says Guoping Feng, the James W. and Patricia Poitras Professor of Neuroscience at MIT and a member of MIT’s McGovern Institute for Brain Research.

Feng and Christopher Moore, a professor of neuroscience at Brown University, are the senior authors of the paper, which appears today in Nature Neuroscience. McGovern Institute research scientist Qian Chen and Brown postdoc Christopher Deister are the lead authors of the study.

The Shank3 protein is important for the function of synapses—connections that allow neurons to communicate with each other. Feng has previously shown that mice lacking the Shank3 gene display many traits associated with autism, including avoidance of social interaction, and compulsive, repetitive behavior.

In the new study, Feng and his colleagues set out to study whether these mice also show sensory hypersensitivity. For mice, one of the most important sources of sensory input is the whiskers, which help them to navigate and to maintain their balance, among other functions.

 

You might also like

People support each other in a community meeting People support each other in a community meeting

New Centre delivers mental healthcare for people with disabilities

The Miles Government is investing $2 million annually towards the…

Close-up of pregnant woman who is holding her stomach in park. Close-up of pregnant woman who is holding her stomach in park.

Obesity in mothers doubles the risk of autism in babies

Children born to mothers with obesity both before and during…

a teenage with autism relaxing with rocking chair a teenage with autism relaxing with rocking chair

New framework launched for Neurodiversity and Mental Health

A groundbreaking article published in the leading psychiatry journal World Psychiatry challenges the traditional…

Multiple sclerosis MS book and prescription and pen. Multiple sclerosis MS book and prescription and pen.

Early intervention reduces long-term disability in children, study finds

New research presented at ECTRIMS 2024 reveals that initiating monoclonal…